Computer Science

Quality plastic surgery studies with Karim Sarhane

Plastic surgery research studies with Karim Sarhane in 2022? We performed a study with rodents and primates that showed this new delivery method provided steady release of IGF-1 at the target nerve for up to 6 weeks,” Dr. Karim Sarhane reported. Compared to animals without this hormone treatment, IGF-1 treated animals (rodents and primates) that were injected every 6 weeks showed a 30% increase in nerve recovery. This has the potential to be a very meaningful therapy for patients with nerve injuries. Not only do these results show increased nerve recovery but receiving a treatment every 6 weeks is much easier on a patient’s lifestyle than current available regiments that require daily treatment.

Dr. Karim Sarhane is an MD MSc graduate from the American University of Beirut. Following graduation, he completed a 1-year internship in the Department of Surgery at AUB. He then joined the Reconstructive Transplantation Program of the Department of Plastic and Reconstructive Surgery at Johns Hopkins University for a 2-year research fellowship. He then completed a residency in the Department of Surgery at the University of Toledo (2021). In July 2021, he started his plastic surgery training at Vanderbilt University Medical Center. He is a Diplomate of the American Board of Surgery (2021).

The combination of nanoparticle carriers with hydrogels as a hybrid delivery system has recently come into favor for purposes including passively controlled drug release, stimuli-responsive drug delivery, site-specific drug delivery, and detoxification. The addition of a hydrogel to a nanoparticle delivery system allows for an added level of tunability as well as increased assurance that the nanoparticles remain at the local site of delivery in vivo (Gao et al., 2016; Norouzi et al., 2016). A promising approach being pursued by our group for repair of PNI involves encapsulation of IGF-1 into nanoparticles that provide sustained release of IGF-1 for over 6 weeks. The nanoparticles are then suspended within a biomimetic nanofiber hydrogel composite carrier to facilitate in vivo application and preliminary results have been encouraging (Santos et al., 2016). The approach involves injection of the composite hydrogel into the denervated target muscle and around the nerve distal to the site of injury, such that the released bioactive IGF-1 diffuses through the target tissues. Our unpublished data suggests that IGF-1 does not act on regenerating axons in gradient-dependent fashion, as uniform delivery along the distal nerve results in a robust treatment effect. However, the question of gradient dependence has not been specifically addressed to our knowledge and warrants further investigation. To achieve maximal treatment effect, IGF-1 will likely need to be delivered for the duration of the regenerative period, which can last many months or even years. It is unlikely that an engineered drug delivery system will be developed that can achieve this duration of release with a single dose. We therefore anticipate that interval ultrasound-guided reinjections will be needed, with the dosing schedule being dependent on the duration of drug release.

Recovery with sustained IGF-1 delivery (Karim Sarhane research) : Functional recovery following peripheral nerve injury is limited by progressive atrophy of denervated muscle and Schwann cells (SCs) that occurs during the long regenerative period prior to end-organ reinnervation. Insulin-like growth factor 1 (IGF-1) is a potent mitogen with well-described trophic and anti-apoptotic effects on neurons, myocytes, and SCs. Achieving sustained, targeted delivery of small protein therapeutics remains a challenge.

The amount of time that elapses between initial nerve injury and end-organ reinnervation has consistently been shown to be the most important predictor of functional recovery following PNI (Scheib and Hoke, 2013), with proximal injuries and delayed repairs resulting in worse outcomes (Carlson et al., 1996; Tuffaha et al., 2016b). This is primarily due to denervation-induced atrophy of muscle and Schwann cells (SCs) (Fu and Gordon, 1995).

The amount of time that elapses between initial nerve injury and end-organ reinnervation has consistently been shown to be the most important predictor of functional recovery following PNI (Scheib and Hoke, 2013), with proximal injuries and delayed repairs resulting in worse outcomes (Carlson et al., 1996; Tuffaha et al., 2016b). This is primarily due to denervation-induced atrophy of muscle and Schwann cells (SCs) (Fu and Gordon, 1995). Following surgical repair, axons often must regenerate over long distances at a relatively slow rate of 1–3 mm/day to reach and reinnervate distal motor endplates. Throughout this process, denervated muscle undergoes irreversible loss of myofibrils and loss of neuromuscular junctions (NMJs), thereby resulting in progressive and permanent muscle atrophy. It is well known that the degree of muscle atrophy increases with the duration of denervation (Ishii et al., 1994). Chronically denervated SCs within the distal nerve are also subject to time-dependent senescence. Following injury, proliferating SCs initially maintain the basal lamina tubes through which regenerating axons travel. SCs also secrete numerous neurotrophic factors that stimulate and guide axonal regeneration. However, as time elapses without axonal interaction, SCs gradually lose the capacity to perform these important functions, and the distal regenerative pathway becomes inhospitable to recovering axons (Ishii et al., 1993; Glazner and Ishii, 1995; Grinsell and Keating, 2014).

Quality and affordable offshore hosting company

Offshore server hosting firm by Lyrahosting? Of course, the decision of whether or not to go offshore depends on your specific needs and objectives. There are many advantages to using an offshore Web Host over a traditional hosting company. These include the fact that Offshore Hosting is generally cheaper, faster and more secure. Offshore Web Hosts are not bound by your country’s laws or rules either. This means they can provide you with services which may even be illegal in your country, but also makes it easier for them to maintain a higher level of security and privacy compared to traditional Web Hosts which operate out of your country and are therefore bound to the rules and laws that your country follows. See more information on https://lyrahosting.com/10gbps-dedicated-servers/.

Offshore Hosting is a Bitcoin Hosting : Offshore hosting, sometimes called bitcoin hosting, offers payment plans that include Bitcoin as the most anonymous payment method. Although the bitcoin price is quite volatile, it’s the ideal payment for anonymous hosting, thanks to its decentralised nature and anonymity. When it comes to payments for hosting fees, a bitcoin wallet is all you need, and when setting one up, you don’t have to provide any personally identifiable information. Platforms like Coinbase let you buy Bitcoin easily and securely. Then you can transfer your funds to any BTC wallet. Nobody can trace your payments back to you as long as your wallet identity remains unknown. It’s advised to generate a new BTC wallet address for each payment and use this address only once. And remember, never disclose your BTC wallet addresses.

When you opt for offshore vps hosting, Offshore Dedicated Server or Shared WebHosting at lyrahosting, you have the advantage of protection from DDoS attacks. We have an efficient filtration system that has the ability to detect DDoS attacks before they occur. Consequently, most attacks are prevented at the source. Our technology has made it possible to recognise and act upon patterns on the type of traffic the website receives. As a result, any possible DDoS attack is nipped at the source. LyraHosting is offering a Multi-Layer DDoS Prevention to protect you from L3, L4 and L7 attacks.

Shared Hosting vs VPS Hosting: A Comparison! Since knowing the general definitions is not enough, we will provide you with some comparisons between the two hosting types to help you better decide which one works best for you. Security is essential no matter what kind of website you own. Both hosting types are relatively secure and stable methods for hosting your site, but there are some differences. With shared hosting, your site might be affected when there’s an error on another site. Also, if other sites eat up too much of the shared bandwidth, your website might get slowed down. This is especially crucial if your site hits high traffic numbers.

If you are going to host controversial content of any sort, there is a possibility you will run afoul of one or more country’s laws, regulations, or cultural norms. The risk of punishment in the form of jail time, fines, and lawsuits, isn’t your only worry. Authorities in dictatorial countries may seek to remove your content from the internet. By serving your content from a country with robust protection of freedom of speech, you are more likely to be able to avoid having your content forcibly taken down.

For web developers, WordPress brings them the ability to realize their dream website design by using its easy to understand the templating system. On top of that, apart from already providing all its users with thousands upon thousands of free, responsive website templates, WordPress ecosystem is flooded with extensions that bring you drag-and-drop website design capability. A few of the prominent names in the plug-in ecosystem that are coupled with drag-and-drop functionality are Elementor, HeroCSS, etc. With this platform, you can go crazy and make the templates look nothing like they originally did, which gives you lots of flexibility and is ideal for those of us wanting a little bit more freedom.

Protect your identity and financial information from hackers who may be on the prowl with our secure VPS Bitcoin Hosting services. All of our Bitcoin hosting plans come with premium security enhancements to help you enjoy premium web features at the most affordable prices. All Bitcoin transactions are safely secured through military-grade cryptography practices which ensure the strongest level of protection. All Bitcoin hosting plans come with advanced Anti-DDoS protection services for cutting edge hosting. Our overall uptime of network always exceeds 99.9%. We put extensive time into the monitorization and renewal of all technology to maintain this percentage. Our dedicated team of trained technicians monitor Lyra Hosting’s unique infrastructure 24x7x36 for swift support and on-the-spot issue resolution without the need for wait times.

One of the major drawbacks that people face while opting for offshore vps is reduced speed that may hamper business prospects. But if you choose an efficient offshore dedicated server like lyrahosting.com, you will face no such problems. At lyrahosting.com we provide blazing fast, rapid 10 protected and stable SSD web hosting. SSD hosting refers to the usage of modern storage technology, that is reliable, fast and efficient. Unlike hard drives (HDDs), SSDs store information in integrated circuits. This means that there are no moving parts. As a result, SSD is not only faster and more competent as compared to HDDs, there is little or no chance of failing. At lyrahosting.com, our SSD web hosting solutions are run on the largest enterprise SSD. It has been created with the objective of accelerating your websites to an incredible speed. This makes it much faster than regular web hosting. Additionally at lyrahosting.com you can benefit from a dedicated IP for your web hosting. This gives you total and complete control over your domain.

Why are your servers located in Netherlands? Power costs less in Netherlands than any other European or American city and an offshore hosting service can pass on these savings to customers. LyraHosting is a Company established in the Hosting industry and expanding since 2017. With hundreds of servers, our focus is entirely in the quality and professionalism. See additional info at lyrahosting.com. Improved Security: By choosing an offshore dedicated server, you’ll improve the security of your hosted web services. Dedicated servers have enhanced security because, as unlike shared servers, they serve only one user. When one server has multiple users, it is more vulnerable to malware attacks. But when you’re all by yourself in the server space, your server is way more secure. Want to know more about shared vs dedicated servers? Check out our guide.

Wide range of clients: We have a wide range of clients from across continents who have made Lyrahosting their home for end to end, bespoke hosting solutions. Multilingual: Language should not be hindrance to your hosting needs. We are therefore multilingual in our approach. Be it English, Hindi, Urdu or Italian feel free to get in touch with us and you will get all the support you seek.